Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction.

Abstract

We examined whether promoter region polymorphism in the tumor necrosis factor-alpha (TNFalpha) gene at position -308 affects the odds of cerebral infarction (CI). We genotyped 366 CI patients and 610 healthy controls for the same polymorphism. A significant decrease was found for the TNFalpha A allele in CI patients compared with controls (P=0.003). Our finding suggests that TNFalpha promoter region polymorphism is responsible for susceptibility to CI in Koreans.

• Authors: Jae-Young Um, Hyung-Min Kim
• Journal: Brain research. Molecular brain research (Brain Res Mol Brain Res) Vol. 122 Issue 1 Pg. 99-102 (Mar 17 2004) ISSN: 0169-328X [Print] Netherlands
• PMID: 14992821 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Tumor Necrosis Factor-alpha

Topics

• Aged
• Alleles
• Case-Control Studies
• Cerebral Infarction (genetics)
• Chi-Square Distribution
• Female
• Genotype
• Humans
• Korea
• Male
• Middle Aged
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• Promoter Regions, Genetic (genetics)
• Tumor Necrosis Factor-alpha (genetics)