[First experiences with a new radiopharmaceutical for sentinel lymph node detection in malignant melanoma: (99m)Tc colloidal rhenium sulphide].

Abstract

UNLABELLED:

AIM of this study was to localize the sentinel lymph node by lymphoscintigraphy using technetium-99m colloidal rhenium sulphide (Nanocis), a new commercially available radiopharmaceutical. Due to the manufacturers' instructions it is licensed for lymphoscintigraphy.

PATIENTS AND METHODS:

35 consecutive patients with histologically proved malignant melanoma, but without clinical evidence of metastases, were preoperatively examined by injecting 20-40 MBq Nanocis with (mean particle size: 100 nm; range: 50-200 nm) intradermally around the lesion. Additionally blue dye was injected intraoperatively. A hand-held gamma probe guided sentinel node biopsy.

RESULTS:

During surgery, the preoperatively scintigraphically detected sentinel lymph nodes were identified in 34/35 (97%) patients. The number of sentinel nodes per patient ranged from one to four (mean: n = 1.8). Histologically, metastatic involvement of the sentinel lymph node was found in 12/35 (34%) patients; the sentinel lymph node positive-rate (14/63 SLN) was 22%. Thus, it is comparable to the findings of SLN-mapping using other technetium-99m-labeled nanocolloides.

CONCLUSION:

(99m)Tc-bound colloidal rhenium sulphide is also suitable for sentinel node mapping.

• Authors: M Weiss, R A Schmid, C Kunte, B Konz, K Hahn
• Journal: Nuklearmedizin. Nuclear medicine (Nuklearmedizin) Vol. 43 Issue 1 Pg. 10-5 (Feb 2004) ISSN: 0029-5566 [Print] Germany
• Vernacular Title: Erste Erfahrungen mit einem neuen Radiopharmakon für die Wächterlymphknoten - Detektion beim malignen Melanom: (99m)Tc markiertes kolloidales Rheniumsulfid.
• PMID: 14978535 (Publication Type: Journal Article)

Chemical References

• Radiopharmaceuticals
• Technetium Compounds
• technetium Tc 99m rhenium colloid
• Rhenium

Topics

• Adult
• Aged
• Female
• Humans
• Melanoma (diagnostic imaging, pathology)
• Middle Aged
• Radionuclide Imaging
• Radiopharmaceuticals
• Reproducibility of Results
• Rhenium
• Sentinel Lymph Node Biopsy (methods)
• Technetium Compounds