Abstract |
The toxicity and efficacy of two oximes, HLö-7 and pyrimidoxime, were evaluated in mice and compared to those obtained with HI-6. HLö-7 and pyrimidoxime produced 24 h LD50 values of 356 and 291 mg/kg (i.p.), respectively. In combination with atropine (17.4 mg/kg, i.p.), HLö-7 was a very efficient therapy against poisoning by 3 x LD50 dose of soman, sarin and GF and 2 x LD50 dose of tabun with ED50 values of 12.4, 0.31, 0.32 and 25.2 mg/kg, respectively. In contrast, pyrimidoxime was a relatively poor therapy which resulted in ED50 values of greater than 150, 5.88, 100 and 71 mg/kg against poisoning by soman, sarin, GF and tabun, respectively. HLö-7 produced significant (p less than 0.05) reactivation of phosphorylated acetylcholinesterase, in vivo, resulting in 47, 38, 27 and 10% reactivation of sarin, GF, soman and tabun inhibited mouse diaphragm acetylcholinesterase, respectively. HLö-7 also antagonized sarin- induced hypothermia in mice suggesting that it reactivated central acetylcholinesterase. The potential of HLö-7 as a replacement oxime for the treatment of nerve agent poisoning is discussed.
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Authors | J G Clement, A S Hansen, C A Boulet |
Journal | Archives of toxicology
(Arch Toxicol)
Vol. 66
Issue 3
Pg. 216-9
( 1992)
ISSN: 0340-5761 [Print] Germany |
PMID | 1497487
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antidotes
- Cholinesterase Inhibitors
- Cholinesterase Reactivators
- Imidazoles
- Neuromuscular Blocking Agents
- Organophosphates
- Oximes
- Pyridines
- Pyridinium Compounds
- HLo 7
- pyrimidoxime
- Soman
- Sarin
- asoxime chloride
- tabun
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Topics |
- Animals
- Antidotes
(pharmacology)
- Cholinesterase Inhibitors
(poisoning)
- Cholinesterase Reactivators
(pharmacology)
- Imidazoles
(pharmacology, toxicity)
- Lethal Dose 50
- Male
- Mice
- Neuromuscular Blocking Agents
(poisoning)
- Organophosphate Poisoning
- Organophosphates
- Oximes
- Pyridines
(pharmacology, toxicity)
- Pyridinium Compounds
(pharmacology, toxicity)
- Sarin
(poisoning)
- Soman
(poisoning)
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