Periprostatic subendothelial intravascular granulomatosis: a mimic of high-grade intravascular prostatic adenocarcinoma.

Abstract

A rare case of intravascular granulomatous inflammation mimicking intravascular prostatic adenocarcinoma is reported. To the author's knowledge, there have been no previous reports of prostatic or periprostatic intravascular granulomatous inflammation. A 67-year-old man presented with elevated serum prostate specific antigen (PSA) and was found to have a high-grade adenocarcinoma of the prostate. A radical prostatectomy revealed intravascular subendothelial granulomatous inflammation mimicking vascular invasion of a high-grade adenocarcinoma found elsewhere in the prostate. Immunoperoxidase stains confirmed that the subendothelial infiltrate was composed of histiocytes and not tumor cells. Periprostatic subendothelial intravascular granulomatosis is a rare event, which may mimic vascular involvement of high-grade prostatic adenocarcinoma and may result from a previous needle biopsy of the prostate. Possible mechanisms for this finding are discussed. It is important to distinguish this process from high-grade prostatic adenocarcinoma involving blood vessels for obvious clinical reasons.

• Authors: Byron E Crawford, Philip J Daroca, Rodney Davis
• Journal: International journal of surgical pathology (Int J Surg Pathol) Vol. 12 Issue 1 Pg. 75-8 (Jan 2004) ISSN: 1066-8969 [Print] United States
• PMID: 14765279 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prostate-Specific Antigen

Topics

• Adenocarcinoma (complications, pathology, surgery)
• Aged
• Diagnosis, Differential
• Granuloma (complications, pathology, surgery)
• Humans
• Immunohistochemistry
• Male
• Prostate (blood supply)
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (complications, pathology, surgery)
• Prostatitis (complications, pathology, surgery)