A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum.

Abstract

A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

• Authors: Avital Torres, Malka Hochberg, Inna Pergament, Reem Smoum, Valerie Niddam, Valery M Dembitsky, Marina Temina, Inka Dor, Ovadia Lev, Morris Srebnik, Claes D Enk
• Journal: European journal of biochemistry (Eur J Biochem) Vol. 271 Issue 4 Pg. 780-4 (Feb 2004) ISSN: 0014-2956 [Print] England
• PMID: 14764094 (Publication Type: Journal Article)

Chemical References

• Glucosides
• Pyrimidine Dimers
• Pyrrolidines
• Radiation-Protective Agents
• collemin A

Topics

• Ascomycota (chemistry, genetics)
• Cell Line
• Cell Survival (drug effects, radiation effects)
• Erythema (etiology, prevention & control)
• Glucosides (chemistry, pharmacology)
• Humans
• Keratinocytes (cytology, drug effects, radiation effects)
• Lichens (chemistry, genetics)
• Pyrimidine Dimers (chemistry, radiation effects)
• Pyrrolidines (chemistry, pharmacology)
• Radiation-Protective Agents (chemistry, pharmacology)
• Skin (radiation effects)
• Spectrophotometry, Ultraviolet
• Ultraviolet Rays (adverse effects)