Abstract |
The participation of cell adhesion molecules (CAMs) in the establishment of autoimmune and infectious myocarditis is an important matter of investigation and may have therapeutic implication. Trypanosoma cruzi infection induces a CD8-mediated myocarditis in patients with severe cardiomyopathy and experimental animals. Previously, we have proposed that this predominance of CD8+ T-cells is, at least in part, consequence of the differential expression of CAMs on circulating CD8+ lymphocytes. In the present study we investigated the participation of CAMs in shaping the phenotypic nature of the autoimmune CD4-mediated myosin-induced and the CD8-mediated T. cruzi-elicited myocarditis. We provide evidence that the prevalence of a certain T-cell subset inside the inflamed heart reflects the differential profile of the adhesion molecules VLA-4, LFA-1, and ICAM-1 displayed on a large proportion of this particular T-cell population in peripheral blood during the early phase of inflammation. Further, the expression of VCAM-1, ligand for VLA-4, and ICAM-1, counter-receptor for LFA-1, was up-regulated on vascular endothelium and paralleled the entrance of inflammatory cells into the cardiac tissue. Thus, this up-regulated expression of receptors-counter-receptors that regulate T-cell transmigration through the vascular endothelium may have an important role in the pathogenesis of the early phase of both autoimmune and infectious myocarditis.
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Authors | Ana Paula M P Marino, Maria Inês P Azevedo, Joseli Lannes-Vieira |
Journal | Memorias do Instituto Oswaldo Cruz
(Mem Inst Oswaldo Cruz)
Vol. 98
Issue 7
Pg. 945-52
(Oct 2003)
ISSN: 0074-0276 [Print] Brazil |
PMID | 14762523
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cell Adhesion Molecules
- Myosins
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Topics |
- Animals
- CD4-Positive T-Lymphocytes
(immunology)
- CD8-Positive T-Lymphocytes
(immunology)
- Cell Adhesion Molecules
(metabolism)
- Female
- Flow Cytometry
- Mice
- Mice, Inbred C3H
- Myocarditis
(immunology, parasitology)
- Myosins
(immunology, metabolism)
- T-Lymphocyte Subsets
(immunology)
- Trypanosoma cruzi
(immunology)
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