[Effects of treatment with redox agent, blood transfusion and scopolamine on 200 patients with severe chlorphenamidine poisoning].

Abstract

OBJECTIVE:

To verify the effects of treatment with blood transfusion and scopolamine on severe chlorphenamidine poisoning (SCP).

METHODS:

400 patients with severe oral chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection.

RESULTS:

The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01].

CONCLUSION:

Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for chlorphenamidine.

• Authors: Ren-hui He, Jie Du, Bao-xian Yang, Ben-wu Liu, Chang-feng Duan, Zhang-liang Hu, Yu-peng Bai
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 21 Issue 3 Pg. 203-5 (Jun 2003) ISSN: 1001-9391 [Print] China
• PMID: 14761489 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Insecticides
• Mydriatics
• Scopolamine
• Chlorphenamidine

Topics

• Adult
• Antioxidants (therapeutic use)
• Blood Transfusion
• Chlorphenamidine (poisoning)
• Drug Therapy, Combination
• Female
• Humans
• Insecticides (poisoning)
• Male
• Mydriatics (therapeutic use)
• Poisoning (therapy)
• Scopolamine (therapeutic use)
• Treatment Outcome