Abstract | OBJECTIVES: METHODS: The uterine artery intima samples were obtained in connection with surgery of 21 postmenopausal and 51 premenopausal women. The amount of FC, CE and phospholipid fatty acids were measured by gas chromatography after extraction and fractionation and these lipid values were related to menopausal status, age and serum total and low-density lipoprotein ( LDL) cholesterol levels. RESULTS: Premenopausal females had significantly less intimal FC (161 +/- 50 vs. 407 +/- 276 microg/100 mg wet weight, P = 0.003) and CE (19 +/- 34 vs. 305 +/- 348 microg/100 mg wet weight, P = 0.050) and smaller proportion of linoleic acid out of all phospholipid fatty acids (4.2 vs. 7.2%, P = 0.002) than postmenopausal women after adjustment with age. The content of CE (r = 0.34, P = 0.025) and the FC-to-CE ratio (r = -0.45, P = 0.002) correlated with age in premenopausal but not in postmenopausal women. Moreover, the intimal content of CE correlated with the percentage of intimal phospholipid linoleic acid in postmenopausal women (r = 0.79, P = 0.020). The same was true for FC (r = 0.73, P < 0.001). CONCLUSIONS: These results indicate that CE and FC accumulation into the wall of uterine artery depends on menopausal status, independently of age, and that the phospholipid long-chain fatty acid composition differs significantly between premenopausal and postmenopausal women. This suggests that estrogens may be involved in the regulation of artery wall lipid composition.
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Authors | Hannu Jokela, Anne Salomäki, Terho Lehtimäki, Klaus Teisala, Pentti K Heinonen, Risto Aine, Riikka Rontu, Reijo Punnonen |
Journal | Maturitas
(Maturitas)
Vol. 47
Issue 2
Pg. 115-22
(Feb 20 2004)
ISSN: 0378-5122 [Print] Ireland |
PMID | 14757270
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, LDL
- Cholesterol
- Linoleic Acid
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Topics |
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Cholesterol
(metabolism)
- Cholesterol, LDL
(blood)
- Chromatography, Gas
- Female
- Humans
- Linoleic Acid
(metabolism)
- Middle Aged
- Postmenopause
(metabolism)
- Premenopause
(metabolism)
- Tunica Intima
(metabolism)
- Uterus
(blood supply)
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