Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation.

Abstract

The aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain.

• Authors: Rui-Xin Zhang, Lixing Lao, Jian-Tian Qiao, M A Ruda
• Journal: Brain research (Brain Res) Vol. 999 Issue 1 Pg. 135-41 (Feb 27 2004) ISSN: 0006-8993 [Print] Netherlands
• PMID: 14746931 (Publication Type: Journal Article)

Chemical References

• Protein Precursors
• RNA, Messenger
• pre-prodynorphin
• Dynorphins
• Freund's Adjuvant

Topics

• Aging (metabolism, pathology)
• Animals
• Chronic Disease
• Disease Models, Animal
• Dynorphins (genetics, metabolism)
• Freund's Adjuvant
• Functional Laterality (physiology)
• Hyperalgesia (chemically induced, metabolism, physiopathology)
• Immunohistochemistry
• Inflammation (chemically induced, metabolism, physiopathology)
• Male
• Peripheral Nervous System Diseases (metabolism, physiopathology)
• Physical Stimulation
• Posterior Horn Cells (metabolism)
• Protein Precursors (genetics)
• RNA, Messenger (metabolism)
• Rats
• Rats, Sprague-Dawley
• Up-Regulation (physiology)