Abstract | AIM: To study the effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride( DDPH) on brain ischemia injury in rats. METHODS: RESULTS:
DDPH at the dose of 10 mg.kg-1 i.p. 30 min before ischemia decreased the ND 3 h after ischemia. The IS declined 24 h after ischemia as well. Meanwhile, DDPH was found to increase SOD activity and reduce the MDA content, as well as mitigate pathological damage, of neuron after brain ischemia in rats. CONCLUSION:
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Authors | Ling Qu, Wei-ting Wang, Lian-jun Guo, Fang Wang, Qing Lü, Jia-qing Qian |
Journal | Yao xue xue bao = Acta pharmaceutica Sinica
(Yao Xue Xue Bao)
Vol. 38
Issue 10
Pg. 725-7
(Oct 2003)
ISSN: 0513-4870 [Print] China |
PMID | 14730891
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuroprotective Agents
- Phenethylamines
- 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane
- Malondialdehyde
- Superoxide Dismutase
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Topics |
- Animals
- Brain
(metabolism, pathology)
- Brain Ischemia
(metabolism, pathology)
- Female
- Infarction, Middle Cerebral Artery
(pathology)
- Male
- Malondialdehyde
(metabolism)
- Neuroprotective Agents
(pharmacology)
- Phenethylamines
(pharmacology)
- Rats
- Rats, Wistar
- Reperfusion Injury
(metabolism, pathology)
- Superoxide Dismutase
(metabolism)
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