Abstract | OBJECTIVE: STUDY DESIGN: We determined allelic distribution of these polymorphisms in a pilot study of 35 BPD cases and 98 controls. chi2 and regression analysis were performed. RESULTS: GST P1 val105ile distribution differed between the groups, with the more efficient val/val allele predominantly in controls (p< or =0.05). When controlling for race and sex, BPD cases were less likely to be homozygotes for the val/val isoform (OR 0.21, CI: 0.045-0.95, p=0.04) and more likely to possess the less efficient ile isoform (OR 4.5, CI: 1.0-20.7, p=0.05). CONCLUSIONS: This pilot study suggests that BPD is associated with the presence of the GST-P1 105ile allele. Future prospective studies are warranted.
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Authors | Martha H Manar, Milton R Brown, Theresa W Gauthier, Lou Ann S Brown |
Journal | Journal of perinatology : official journal of the California Perinatal Association
(J Perinatol)
Vol. 24
Issue 1
Pg. 30-5
(Jan 2004)
ISSN: 0743-8346 [Print] United States |
PMID | 14726935
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Bronchopulmonary Dysplasia
(diagnosis, genetics)
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Glutathione Transferase
(genetics)
- Humans
- Infant, Newborn
- Male
- Multivariate Analysis
- Pilot Projects
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Probability
- Reference Values
- Sensitivity and Specificity
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