Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.

Abstract

To study the functions of 5-HT4 receptors, a null mutation was engineered in the corresponding gene. 5-HT4 receptor knock-out mice displayed normal feeding and motor behaviors in baseline conditions but abnormal feeding and locomotor behavior in response to stress and novelty. Specifically, stress-induced hypophagia and novelty-induced exploratory activity were attenuated in the knock-out mice. In addition, pentylenetetrazol-induced convulsive responses were enhanced in the knock-out mice, suggesting an increase in neuronal network excitability. These results provide the first example of a genetic deficit that disrupts the ability of stress to reduce feeding and body weight and suggest that 5-HT4 receptors may be involved in stress-induced anorexia and seizure susceptibility.

• Authors: Valérie Compan, Mingming Zhou, Régis Grailhe, Russell A Gazzara, Renee Martin, Jay Gingrich, Aline Dumuis, Daniela Brunner, Joël Bockaert, René Hen
• Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci) Vol. 24 Issue 2 Pg. 412-9 (Jan 14 2004) ISSN: 1529-2401 [Electronic] United States
• PMID: 14724239 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Convulsants
• Receptors, Serotonin, 5-HT4
• Pentylenetetrazole

Topics

• Animals
• Behavior, Animal
• Body Weight
• Convulsants
• Eating
• Environment
• Gene Targeting
• Locomotion
• Mice
• Mice, Knockout
• Nerve Net (physiopathology)
• Pentylenetetrazole
• Receptors, Serotonin, 5-HT4 (genetics, physiology)
• Seizures (chemically induced, etiology, physiopathology)
• Stress, Physiological (complications)