Early relapse after non myeloablative allogeneic stem cell transplantation in a patient with acute promyelocytic leukemia in complete molecular remission.

Abstract

We described a 41-year-old patient with acute promyelocytic leukemia (APL) who experienced two successive relapses: one after all-trans retinoic acid (ATRA) treatment and chemotherapy, and another after ATRA treatment and chemotherapy, followed by autologous peripheral blood stem cell transplantation. A third complete remission (CR) was achieved with arsenic trioxide (As2O3) therapy. Mini-transplantation was performed as consolidation therapy. While the patient was in molecular remission at the beginning of conditioning regimen, a new relapse arose after transplantation at time of cell recovery. This raises a potential relationship between relapse and the severe immunosuppression induced by mini-transplantation. To our knowledge, this is the first description of a mini-allograft in an APL patient achieving molecular remission after As2O3 therapy.

• Authors: E Tavernier, X Thomas
• Journal: Indian journal of cancer (Indian J Cancer) 2003 Oct-Dec Vol. 40 Issue 4 Pg. 140-3 ISSN: 0019-509X [Print] India
• PMID: 14716110 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Arsenicals
• Oxides
• Tretinoin
• Arsenic Trioxide

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Arsenic Trioxide
• Arsenicals (therapeutic use)
• Drug Resistance, Neoplasm
• Humans
• Leukemia, Promyelocytic, Acute (drug therapy)
• Male
• Neoplasm Recurrence, Local
• Oxides (therapeutic use)
• Remission Induction
• Stem Cell Transplantation
• Transplantation, Homologous
• Tretinoin (therapeutic use)