Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: The incidence of the AWS after first, second and third line hormonal therapy was 35.8%, 8.0% and 0%, respectively. The efficiency of subsequent hormonal therapy was not related to the occurrence of the AWS. Nonsteroidal antiandrogens as alternative therapies for disease relapse from primary therapy were effective in second line (FLT 38.1%, BCL 44.4%) or in third line (FLT 30.0%, BCL 28.6%) hormonal therapy. Of 5 (80%) patients who responded to second line therapy 4 (80%) had effective third line therapy, while only 1 of 12 (8.3%) second line nonresponders had effective third line therapy (p = 0.003). The survival of second line responders was significantly better than that of nonresponders (5-year survival rate 92.3% vs 23.9%, p <0.001), indicating a potential predictive value for second line responsiveness. No significant clinical factor identified second line responsiveness. CONCLUSIONS: Subsequent nonsteroidal antiandrogen therapies were effective against prostate cancer relapse after hormonal therapy. The response to third line therapy was more effective and survival was improved from the time of first line therapy relapse among second line responders than that in nonresponders. Our data support the notion that second line responders are androgen independent but still hormonally sensitive.
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Authors | Satoko Kojima, Hiroyoshi Suzuki, Koichiro Akakura, Masaki Shimbo, Tomohiko Ichikawa, Haruo Ito |
Journal | The Journal of urology
(J Urol)
Vol. 171
Issue 2 Pt 1
Pg. 679-83
(Feb 2004)
ISSN: 0022-5347 [Print] United States |
PMID | 14713785
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgen Antagonists
- Anilides
- Antineoplastic Agents, Hormonal
- Nitriles
- Tosyl Compounds
- Flutamide
- bicalutamide
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Topics |
- Aged
- Aged, 80 and over
- Androgen Antagonists
(therapeutic use)
- Anilides
(therapeutic use)
- Antineoplastic Agents, Hormonal
(therapeutic use)
- Flutamide
(therapeutic use)
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy, mortality)
- Nitriles
- Prostatic Neoplasms
(drug therapy, mortality)
- Substance Withdrawal Syndrome
(epidemiology)
- Survival Rate
- Tosyl Compounds
- Treatment Failure
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