Abstract | AIM: METHODS: RESULTS: Total urinary symptom scores (International Prostate Symptom Score, IPSS) remained unchanged after the cholinergic therapy, but were significantly lower after the alpha-blocker treatment (P = 0.0001) and the combination therapy (P = 0.0001). With regard to the total IPSS, there were significant differences between the cholinergic and the alpha-blocker groups (P = 0.0008), and also between the cholinergic and combination groups (P = 0.0033), in favor of the latter. The average and maximum flow rates did not increase significantly after monotherapy with either the cholinergic drug or the alpha-blocker, but they significantly increased after combination therapy compared to baseline values (P = 0.0033 and P= 0.0004, respectively). Postvoid residual volume did not decrease significantly after the cholinergic drug therapy, but decreased significantly after the alpha-blocker (P = 0.0043) and the combination therapies (P = 0.0008). The percentage of residual urine decreased significantly after therapy in all groups (P = 0.0005, P= 0.0176 and P= 0.0001, respectively). CONCLUSION:
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Authors | Tomonori Yamanishi, Kosaku Yasuda, Takao Kamai, Toshihiko Tsujii, Ryuji Sakakibara, Tomoyuki Uchiyama, Ken-ichiro Yoshida |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 11
Issue 2
Pg. 88-96
(Feb 2004)
ISSN: 0919-8172 [Print] Australia |
PMID | 14706012
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic alpha-Antagonists
- Cholinergic Agents
- Piperazines
- Pyridinium Compounds
- Bethanechol
- urapidil
- distigmine
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Topics |
- Administration, Oral
- Adrenergic alpha-Antagonists
(administration & dosage)
- Adult
- Aged
- Bethanechol
(administration & dosage)
- Cholinergic Agents
(administration & dosage)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Piperazines
(administration & dosage)
- Probability
- Prospective Studies
- Pyridinium Compounds
(administration & dosage)
- Severity of Illness Index
- Single-Blind Method
- Treatment Outcome
- Urinary Retention
(diagnosis, drug therapy)
- Urination Disorders
(diagnosis, drug therapy)
- Urodynamics
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