Chronic intoxication with 3-nitropropionic acid in rats induces the loss of striatal dopamine terminals without affecting nigral cell viability.

Abstract	3-Nitropropionic acid (3NP) is a succinate dehydrogenase inhibitor allowing the generation of animal models of Huntington's disease. In the present study, we found that a 5-day continuous chronic infusion of 3NP produces loss of [3H]mazindol binding and tyrosine hydroxylase (TH) immunoreactivity in the striatal area of degeneration. This loss of dopamine terminals was not due to a loss of nigral neurons since the expression of TH as well as the number of TH-expressing neurons remained unaltered in the substantia nigra of rats treated by 3NP. This suggests that the 3NP-induced dopamine terminal loss is secondarily related to the striatal degeneration andlor to a direct effect of 3NP on striatal terminals and not to a primary effect on nigral cells.
Authors	David Blum, Marie-Christine Galas, Laetitia Cuvelier, Serge N Schiffmann
Journal	Neuroscience letters (Neurosci Lett) Vol. 354 Issue 3 Pg. 234-8 (Jan 16 2004) ISSN: 0304-3940 [Print] Ireland
PMID	14700739 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antihypertensive Agents Isoenzymes Nitro Compounds Propionates RNA, Messenger Tritium Mazindol Carbohydrate Dehydrogenases sorbose dehydrogenase Tyrosine 3-Monooxygenase Glutamate Decarboxylase glutamate decarboxylase 1 3-nitropropionic acid Dopamine
Topics	Animals Antihypertensive Agents (toxicity) Binding Sites Carbohydrate Dehydrogenases (metabolism) Cell Survival (drug effects) Corpus Striatum (cytology, drug effects, enzymology, metabolism) Dopamine (metabolism) Glutamate Decarboxylase (genetics, metabolism) Immunohistochemistry In Situ Hybridization Isoenzymes (genetics, metabolism) Male Mazindol (metabolism) Nitro Compounds Presynaptic Terminals (drug effects, metabolism) Propionates (toxicity) RNA, Messenger (metabolism) Rats Rats, Inbred Lew Reverse Transcriptase Polymerase Chain Reaction Substantia Nigra (cytology, drug effects, enzymology) Tritium (metabolism) Tyrosine 3-Monooxygenase (metabolism)

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