Abstract | BACKGROUND/AIMS: The role of COX-2 for renal function during renal development, for physiology and pathophysiology of renal diseases and the side effects of available COX-2 inhibitors, has gained increasing interest. We aimed therefore to review the respective role of renal COX-2. METHODS: Review of relevant recent publications in the field, and in addition of in part unpublished data obtained in our laboratories. RESULTS: COX-2 is 'constitutively' localized in the kidney i.e. in macula densa, TALH, interstitial cells, and is of utmost importance for normal renal development. Renal COX-2 is regulated by for example sodium and volume intake, angiotensin II, glucocorticoids often involving specific COX-2 promotor response elements. COX-2 derived prostanoids are required for preservation of renal blood flow and glomerular filtration especially in states of fluid deficit, they promote natriuresis, and furthermore may stimulate renin secretion during low- sodium intake/ loop diuretic use. Conversely, COX-2 inhibitors decrease glomerular filtration, and renal perfusion, sometimes even causing acute renal failure. In addition, COX-2 inhibitors cause sodium retention, edema formation, cardiac failure and hypertension. The role of COX-2 derived prostanoids in renal inflammation or failure including diabetic nephropathy and renal transplantation remains at present controversial. CONCLUSION: COX-2 is one of the major players in renal physiology and pathophysiology. One focus of future work should be placed on COX-2 in primary renal diseases.
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Authors | Bernhard K Krämer, Martin C Kammerl, Martin Kömhoff |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 27
Issue 1
Pg. 43-62
( 2004)
ISSN: 1420-4096 [Print] Switzerland |
PMID | 14691350
(Publication Type: Journal Article, Review)
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Copyright | Copyright 2004 S. Karger AG, Basel |
Chemical References |
- Isoenzymes
- Membrane Proteins
- Cyclooxygenase 2
- PTGS2 protein, human
- Prostaglandin-Endoperoxide Synthases
- Renin
|
Topics |
- Animals
- Cyclooxygenase 2
- Humans
- Isoenzymes
(metabolism, physiology)
- Kidney
(enzymology, growth & development, physiology)
- Kidney Diseases
(physiopathology)
- Membrane Proteins
- Natriuresis
(physiology)
- Nephritis
(metabolism)
- Prostaglandin-Endoperoxide Synthases
(metabolism, physiology)
- Renin
(metabolism)
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