Amino acids as regulators of gene expression: molecular mechanisms.

Abstract

Regulation of gene expression by nutrients in mammals is an important mechanism allowing them to adapt their physiological functions according to the supply of nutrient in the diet. It has been shown recently that amino acids are able to regulate by themselves the expression of numerous genes. CHOP, asparagine synthetase, and IGFBP-1 regulation following AA starvation will be described in this review with special interest in the molecular mechanisms involved.

• Authors: Céline Jousse, Julien Averous, Alain Bruhat, Valérie Carraro, Sylvie Mordier, Pierre Fafournoux
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 313 Issue 2 Pg. 447-52 (Jan 09 2004) ISSN: 0006-291X [Print] United States
• PMID: 14684183 (Publication Type: Journal Article, Review)

Chemical References

• ATF4 protein, human
• Amino Acids
• CCAAT-Enhancer-Binding Proteins
• DDIT3 protein, human
• Insulin-Like Growth Factor Binding Protein 1
• Transcription Factors
• Activating Transcription Factor 4
• Transcription Factor CHOP
• Aspartate-Ammonia Ligase

Topics

• Activating Transcription Factor 4
• Amino Acids (pharmacology, physiology)
• Animals
• Aspartate-Ammonia Ligase (metabolism)
• CCAAT-Enhancer-Binding Proteins (genetics, metabolism)
• Dietary Supplements
• Gene Expression Regulation (drug effects, physiology)
• Humans
• Insulin-Like Growth Factor Binding Protein 1 (metabolism)
• Starvation (metabolism)
• Stress, Physiological (metabolism)
• Transcription Factor CHOP
• Transcription Factors (genetics, metabolism)
• Transcription, Genetic