Insulin resistance in latent autoimmune diabetes of adulthood.

Abstract

Insulin resistance in patients with latent autoimmune diabetes of adulthood (LADA) was determined by homeostasis model assessment (HOMA). LADA was identified by a clinical phenotype of type 2 diabetes with antibodies to GAD65 and/or IA-2/ICA512. All patients were managed with insulin therapy. Insulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type 1 diabetes, and similar to that in long-term type 1 diabetes. Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. LADA resembles long-term type 1 diabetes with respect to insulin resistance and BMI, but occurs at an older age.

• Authors: M T Behme, J Dupre, S B Harris, I M Hramiak, J L Mahon
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1005 Pg. 374-7 (Nov 2003) ISSN: 0077-8923 [Print] United States
• PMID: 14679095 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• ICA512 autoantibody
• Isoenzymes
• Glutamate Decarboxylase
• glutamate decarboxylase 2

Topics

• Adult
• Autoantibodies (analysis)
• Diabetes Mellitus, Type 1 (immunology, physiopathology)
• Diabetes Mellitus, Type 2 (immunology, physiopathology)
• Female
• Glutamate Decarboxylase (immunology)
• Humans
• Insulin Resistance
• Isoenzymes (immunology)
• Male
• Middle Aged