Relationships between S-100 protein-positive cells and clinicopathological factors in patients with colorectal cancer.

Abstract

BACKGROUND:

An increased number of dendritic cells (DCs), as indicated by positive S-100 protein staining, has been shown to correlate with good prognosis in several malignancies. The clinicopathological significance of S-100 protein-positive cells in human colorectal cancer is unclear and was thus examined.

PATIENTS AND METHODS:

We investigated the relationships between the density of S-100 protein-positive cells at the peripheral area of the tumor, prognosis and clinicopathological factors in 30 patients with colorectal cancer. S-100 protein-positive cells were detected by immunohistochemistry using a mouse monoclonal antibody against S-100 protein.

RESULTS:

The number of S-100 protein-positive cells was significantly higher in patients with a good prognosis or those without recurrence or worsening of their condition, but was significantly lower in patients with lymph node metastasis, T3-T4, hepatic metastasis or tumors more advanced than stage III (TNM).

CONCLUSION:

S-100 protein-positive cells may act as one line of defense against malignant cells in patients with colorectal cancer.

• Authors: Yoshifumi Nakayama, Yuzuru Inoue, Noritaka Minagawa, Takefumi Katsuki, Nobuo Nagashima, Koji Onitsuka, Yosuke Tsurudome, Tatsuhiko Sako, Keiji Hirata, Naoki Nagata, Hideaki Itoh
• Journal: Anticancer research (Anticancer Res) 2003 Nov-Dec Vol. 23 Issue 6a Pg. 4423-6 ISSN: 0250-7005 [Print] Greece
• PMID: 14666729 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• S100 Proteins

Topics

• Adult
• Aged
• Colorectal Neoplasms (immunology, metabolism, pathology)
• Dendritic Cells (immunology, metabolism)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• S100 Proteins (immunology, metabolism)