Abstract | BACKGROUND: METHODS AND RESULTS: Serum specimens from 201 healthy asymptomatic subjects (52% male; mean age, 56.6 years) undergoing electron-beam computed tomographic imaging were used to measure levels of mHSP65 and human HSP60 antibodies and antibodies to several infectious pathogens. We found that 84% of the study subjects had anti-mHSP65 IgG antibodies. Mean titers of mHSP65 antibodies were higher (1:394 versus 1:267, P=0.012) in individuals with than in those without elevated levels of coronary calcium ( calcium score > or =150). Increasing titers of mHSP65 antibodies were significantly associated, in a dose-response manner, with elevated levels of coronary calcification. Individuals with the highest titers of mHSP65 antibodies (> or =1:800) had an adjusted odds ratio (OR) of 14.3 for having elevated coronary calcium (P=0.004). Association of mHSP65 antibodies with elevated coronary calcification levels was independent of CAD risk factors after multivariate adjustment (P=0.037). Interestingly, mHSP65 antibody titers were correlated with Helicobacter pylori infection (P=0.004), which maintained significance after adjustment for CAD risk factors and seropositivities to other pathogens (adjusted OR, 3.1; 95% CI, 1.4 to 6.6). No association was found between antibodies to human HSP60 and levels of coronary calcification. CONCLUSIONS:
Antibodies to mHSP65 are associated with elevated levels of coronary calcification and correlated with H pylori infection, suggesting that pathogen-triggered autoimmunity plays a role in early atherosclerosis.
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Authors | Jianhui Zhu, Richard J Katz, Arshed A Quyyumi, Daniel A Canos, David Rott, Gyorgy Csako, Alexandra Zalles-Ganley, Jibike Ogunmakinwa, Alan G Wasserman, Stephen E Epstein |
Journal | Circulation
(Circulation)
Vol. 109
Issue 1
Pg. 36-41
(Jan 06 2004)
ISSN: 1524-4539 [Electronic] United States |
PMID | 14662717
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Bacterial
- Autoantibodies
- Bacterial Proteins
- Chaperonin 60
- heat-shock protein 65, Mycobacterium
- Chaperonins
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Topics |
- Adult
- Aged
- Antibodies, Bacterial
(blood)
- Autoantibodies
(blood)
- Autoimmunity
- Bacterial Proteins
(immunology)
- Calcinosis
(immunology, microbiology)
- Chaperonin 60
(immunology)
- Chaperonins
(immunology)
- Coronary Artery Disease
(immunology, microbiology, pathology)
- Female
- Helicobacter Infections
(complications, immunology)
- Helicobacter pylori
- Humans
- Infections
(immunology)
- Male
- Middle Aged
- Risk Factors
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