N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease.

Abstract

OBJECTIVES:

We sought to examine whether measurements of N-terminal pro-brain natriuretic peptide (NT-proBNP), in addition to cardiac troponin T (cTnT) and interleukin-6 (IL-6), improve the ability to identify high-risk patients who benefit from an early invasive strategy.

BACKGROUND:

Biochemical indicators of cardiac performance (e.g., NT-proBNP), inflammation (e.g., IL-6), and myocardial damage (e.g., cTnT) predict mortality in unstable coronary artery disease (UCAD) (i.e., unstable angina or non-ST-segment elevation myocardial infarction [MI]). In these patients, an early invasive treatment strategy improves the outcome.

METHODS:

Levels of NT-proBNP, cTnT, and IL-6 were measured in 2,019 patients with UCAD randomized to an invasive or non-invasive strategy in the FRagmin and fast revascularization during InStability in Coronary artery disease (FRISC-II) trial. Patients were followed up for two years to determine death and MI.

RESULTS:

Patients in the third NT-proBNP tertile had a 4.1-fold (95% confidence interval [CI] 2.4 to 7.2) and 3.5-fold (95% CI 1.8 to 6.8) increased mortality in the non-invasive and invasive groups, respectively. An increased NT-proBNP level was independently associated with mortality. In patients with increased levels of both NT-proBNP and IL-6, an early invasive strategy reduced mortality by 7.3% (risk ratio 0.46, 95% CI 0.21 to 1.00). In patients with lower NT-proBNP or IL-6 levels, the mortality was not reduced. Only elevated cTnT was independently associated with future MI and a reduction of MI by means of an invasive strategy.

CONCLUSIONS:

N-terminal proBNP is independently associated with mortality. The combination of NT-proBNP and IL-6 seems to be a useful tool in the identification of patients with a definite survival benefit from an early invasive strategy. Only cTnT is independently associated with future MI and a reduction of MI by an invasive strategy.

• Authors: Tomas Jernberg, Bertil Lindahl, Agneta Siegbahn, Bertil Andren, Gunnar Frostfeldt, Bo Lagerqvist, Mats Stridsberg, Per Venge, Lars Wallentin
• Journal: Journal of the American College of Cardiology (J Am Coll Cardiol) Vol. 42 Issue 11 Pg. 1909-16 (Dec 03 2003) ISSN: 0735-1097 [Print] United States
• PMID: 14662251 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Interleukin-6
• Nerve Tissue Proteins
• Peptide Fragments
• Troponin T
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Adult
• Aged
• Angina, Unstable (blood)
• Biomarkers (blood)
• Coronary Angiography
• Coronary Disease (blood, mortality, pathology)
• Echoencephalography
• Humans
• Inflammation (blood)
• Interleukin-6 (blood)
• Male
• Middle Aged
• Myocardial Infarction (blood)
• Natriuretic Peptide, Brain
• Necrosis
• Nerve Tissue Proteins (blood)
• Peptide Fragments (blood)
• Prognosis
• Troponin T (blood)