Abstract | UNLABELLED: METHODS: We conducted a population-based case-control study. Participants were health maintenance organization members aged 30 to 79 years with treated hypertension. Those who survived incident stroke (n = 116) or MI (n = 208) during the study period were designated as cases. Control subjects (n = 717) were randomly sampled and frequency-matched to MI cases on age, sex, and calendar year. Health history, medication use, and AGT genotype were assessed. RESULTS: ThrThr genotype was present in 21% of stroke cases, 26% of MI cases, and 19% of control subjects. Compared with nonuse, ACE inhibitor use was associated with lower stroke risk among Thr homozygotes (odds ratio [OR] = 0.37, 95% CI = 0.14 to 0.99) than among Met carriers (OR = 1.4, 95% CI = 0.88 to 2.4; P for interaction =.02). Compared with nonuse, ACE inhibitor use was associated with similar MI risk among Thr homozygotes (OR = 0.90, 95% CI = 0.62 to 1.3) and among Met carriers (OR = 1.2, 95% CI = 0.60 to 2.5; P for interaction = 0.5). CONCLUSIONS: In this hypertensive population, the association of ACE inhibitor use with risk of nonfatal stroke varied by genotype. The protective association between ACE inhibitor use and nonfatal stroke risk among individuals with ThrThr genotype was not observed for nonfatal MI.
|
Authors | Joshua C Bis, Nicholas L Smith, Bruce M Psaty, Susan R Heckbert, Karen L Edwards, Rozenn N Lemaitre, Thomas Lumley, Frits R Rosendaal |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 16
Issue 12
Pg. 1011-7
(Dec 2003)
ISSN: 0895-7061 [Print] United States |
PMID | 14643574
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Angiotensinogen
|
Topics |
- Adult
- Aged
- Alleles
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Angiotensinogen
(genetics)
- Case-Control Studies
- Female
- Genotype
- Humans
- Hypertension
(complications, drug therapy, genetics)
- Male
- Middle Aged
- Myocardial Infarction
(epidemiology, etiology, genetics)
- Polymorphism, Genetic
(genetics)
- Risk
- Stroke
(epidemiology, etiology, genetics)
|