The hypertriglyceridemic waist phenotype among women.

Abstract

BACKGROUND:

Elevated plasma triglycerides (TG) and waist girth (hypertriglyceridemic waist (HTGW)) has been associated with elevated insulin, small dense low-density lipoprotein (sLDL) particles, and Apo B in men. The HTGW has not been reported for women and the effect of cardiorespiratory fitness ("fitness") on associations between HTGW and coronary risk factors is unknown.

PURPOSE:

To determine the prevalence of HTGW and the influence of fitness on the relationship between HTGW and coronary risk among 137 healthy women (54+/-9 year; body mass index (BMI)=28+/-6 kg/m(2)).

METHODS:

HTGW was defined as waist girth >88 cm and TG >150 mg/dl. The metabolic triad was defined as insulin >31 pmol/l, Apo B >69 mg/dl and LDL-C >84 mg/dl. Fitness was assessed with a maximal treadmill exercise test.

RESULTS:

The sample prevalence of HTGW (n=15) was 11% (95% CI=5.7-16.0%). Apo B (P=0.04) and insulin (P=0.0001) increased across quintiles of waist girth, and LDL-C (P=0.004) increased across quintiles of TG. Metabolic triad prevalence was highest (67%, n=10) among HTGW women and lowest (22%, n=26) among non-HTGW women. A trend for higher coronary heart disease CHD risk factors was observed among HTGW compared with non-HTGW women. Among the HTGW group, a trend for lower CHD risk factors was observed among fit (>or=6.5 METs, n=7) versus unfit women (<6.5 METs, n=8). Sample size limitations prohibited meaningful tests of significant differences in CHD risk factors when stratified simultaneously on HTGW and fitness status.

CONCLUSIONS:

HTGW is associated with increased coronary risk factors similarly among women as reported for men. Higher fitness may improve the CHD risk profile among women with HTGW.

• Authors: Michael J LaMonte, Barbara E Ainsworth, Katrina D DuBose, Peter W Grandjean, Paul G Davis, Frank G Yanowitz, J Larry Durstine
• Journal: Atherosclerosis (Atherosclerosis) Vol. 171 Issue 1 Pg. 123-30 (Nov 2003) ISSN: 0021-9150 [Print] Ireland
• PMID: 14642414 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Apolipoproteins B
• Biomarkers
• Cholesterol, HDL
• Cholesterol, LDL
• Insulin
• Triglycerides
• C-Reactive Protein

Topics

• Apolipoproteins B (blood)
• Biomarkers (blood)
• Blood Pressure (physiology)
• Body Composition (genetics)
• Body Mass Index
• C-Reactive Protein (metabolism)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Disease (blood, epidemiology, genetics)
• Cross-Sectional Studies
• Female
• Humans
• Hypertriglyceridemia (blood, epidemiology, genetics)
• Insulin (blood)
• Middle Aged
• Obesity (blood, epidemiology, genetics)
• Phenotype
• Physical Fitness (physiology)
• Prevalence
• Risk Factors
• Statistics as Topic
• Triglycerides (blood)
• Women's Health