Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid: a useful marker for the diagnosis of normal pressure hydrocephalus.

Abstract

Lipocalin-type prostaglandin D synthase (PGDS) is considered to be mainly produced in the leptomeninges and secreted into cerebrospinal fluid (CSF). We found PGDS levels in CSF of patients with normal pressure hydrocephalus (NPH) (8.99+/-2.59 microg/ml, mean+/-S.D., n=14) to be significantly lower than levels in a control (15.29+/-5.17, n=14, P<0.0001) and other dementia group (19.14+/-4.34, n=7, P=0.0003). Thus, PGDS level in CSF is a useful marker for the differential diagnosis of NPH from other diseases with dementia.

• Authors: Mitsuhito Mase, Kazuo Yamada, Naoki Shimazu, Kosuke Seiki, Hiroshi Oda, Hiroya Nakau, Takashi Inui, Weidong Li, Naomi Eguchi, Yoshihiro Urade
• Journal: Neuroscience research (Neurosci Res) Vol. 47 Issue 4 Pg. 455-9 (Dec 2003) ISSN: 0168-0102 [Print] Ireland
• PMID: 14630351 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Lipocalins
• Intramolecular Oxidoreductases
• prostaglandin R2 D-isomerase

Topics

• Aged
• Aged, 80 and over
• Biomarkers (cerebrospinal fluid)
• Dementia (cerebrospinal fluid)
• Diagnosis, Differential
• Female
• Humans
• Hydrocephalus, Normal Pressure (cerebrospinal fluid)
• Intramolecular Oxidoreductases (cerebrospinal fluid)
• Lipocalins
• Male
• Middle Aged