Abstract | PURPOSE OF REVIEW: The recent literature was reviewed to analyze the developments in the diagnosis, pathogenesis, and immunology of this group of paraneoplastic syndromes. Clinical features and pathologic findings are summarized. RECENT FINDINGS: SUMMARY: Further research into the functional role of recoverin in cancer cells may advance our understanding in cancer immunology. Immunotherapy may be possible if a specific epitope of recoverin can be found to contain the antigenic site for antitumor antibodies and not cross-react with retinal antigens. Research into the pathogenesis of the other paraneoplastic syndromes is required for a better understanding and treatment of these rare conditions. The missing link between primary cutaneous melanoma and uveal melanocytes still eludes investigators in bilateral diffuse uveal melanocytic proliferation. The discovery of the missing link may provide us with some understanding of the development of uveal melanoma.
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Authors | Cecilia P W Ling, Carlos Pavesio |
Journal | Current opinion in ophthalmology
(Curr Opin Ophthalmol)
Vol. 14
Issue 6
Pg. 426-32
(Dec 2003)
ISSN: 1040-8738 [Print] United States |
PMID | 14615650
(Publication Type: Journal Article, Review)
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Topics |
- Diagnostic Techniques, Ophthalmological
- Eye Neoplasms
(complications)
- Humans
- Paraneoplastic Syndromes
(complications, diagnosis, therapy)
- Vision Disorders
(etiology)
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