Abstract |
Several prostanoids were investigated for a potential to induce emesis in Suncus murinus. The TP receptor agonist 11alpha,9alpha-epoxymethano-15S-hydroxyprosta-5Z,13E-dienoic acid ( U46619) induced emesis at doses as low as 3 microg/kg, i.p. but the DP receptor agonist 5-(6-Carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin (BW245C) was approximately 1000 times less potent. The emetic action of U46619 (300 microg/kg, i.p.) was antagonized significantly by the TP receptor antagonist, vapiprost (P<0.05). EP ( prostaglandin E(2), 17-phenyl-omega-trinor prostaglandin E(2), misoprostol and sulprostone), FP ( prostaglandin F(2alpha) and fluprostenol) and IP ( iloprost and cicaprost) receptor agonists failed to induce consistent emesis at doses up to 300-1000 microg/kg, i.p. Fluprostenol reduced nicotine (5 mg/kg, s.c.)-but not copper sulphate (120 mg/kg, intragastric)-induced emesis; the other inconsistently emetic prostanoids were inactive to modify drug-induced emesis. The results indicate an involvement of TP and possibly DP and FP receptors in the emetic reflex of S. murinus.
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Authors | Kelvin K W Kan, Robert L Jones, Man P Ngan, John A Rudd |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 477
Issue 3
Pg. 247-51
(Sep 23 2003)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 14522363
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biphenyl Compounds
- Heptanoic Acids
- Hydantoins
- Prostaglandins
- Prostaglandins F, Synthetic
- Receptors, Thromboxane
- fluprostenol
- Nicotine
- BW 245C
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
- vapiprost
- Copper Sulfate
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Topics |
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
(administration & dosage, adverse effects, antagonists & inhibitors)
- Animals
- Biphenyl Compounds
(administration & dosage, pharmacokinetics, therapeutic use)
- Copper Sulfate
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Female
- Heptanoic Acids
(administration & dosage, pharmacokinetics, therapeutic use)
- Hydantoins
(administration & dosage)
- Injections, Intraperitoneal
- Injections, Subcutaneous
- Intubation, Gastrointestinal
- Male
- Nausea
(physiopathology)
- Nicotine
(administration & dosage, adverse effects, antagonists & inhibitors)
- Prostaglandins
(administration & dosage, adverse effects)
- Prostaglandins F, Synthetic
(administration & dosage, pharmacokinetics, therapeutic use)
- Reaction Time
- Receptors, Thromboxane
(drug effects, physiology)
- Shrews
(physiology)
- Time Factors
- Vomiting
(chemically induced, physiopathology, prevention & control)
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