[Significance of alpha 2,6-specific sialyltransferase ST6N and alpha 2,3-specific sialyltransferase ST3N in stomach carcinoma].

Abstract

The objective of this prospective study was to investigate the role of sialytransferase activities in patients with gastric cancer. In patients with gastric cancer we observed a significant correlation between sialyltransferase ST6N levels and survival after a median follow up of one year. High ST6N levels in the tumor and the surrounding normal mucosa were associated with poor prognosis. The results of this pilot study encourage further evaluation of sialyltransferase in patients with gastric cancer.

• Authors: S Gretschel, W Kemmner, J Fischer, P M Schlag
• Journal: Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress (Langenbecks Arch Chir Suppl Kongressbd) Vol. 115 Issue Suppl I Pg. 475-8 ( 1998) ISSN: 0942-2854 [Print] Germany
• Vernacular Title: Bedeutung der alpha 2,6-spezifischen Sialyltransferase ST6N und der alpha 2,3-spezifischen Sialytransferase ST3N beim Magenkarzinom.
• PMID: 14518301 (Publication Type: English Abstract, Journal Article)

Chemical References

• Sialyltransferases
• beta-D-Galactoside alpha 2-6-Sialyltransferase
• beta-Galactoside alpha-2,3-Sialyltransferase
• ST3GAL1 protein, human

Topics

• Biopsy
• Gastrectomy
• Gastric Mucosa (enzymology, pathology)
• Gastroscopy
• Humans
• Prognosis
• Prospective Studies
• Sialyltransferases (metabolism)
• Stomach Neoplasms (enzymology, mortality, pathology, surgery)
• Survival Rate
• beta-D-Galactoside alpha 2-6-Sialyltransferase
• beta-Galactoside alpha-2,3-Sialyltransferase