Abstract |
The baculovirus-derived extracellular domain of the CO17-1A antigen induced cellular and/or humoral immune responses in curatively resected colorectal and pancreatic cancer patients after at least three applications of the vaccine. The vaccine application was safe and non-toxic. The clinical efficacy of the vaccine needs to be evaluated in larger, randomized clinical trials.
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Authors | L Staib, H Braumüller, C Leeser, H G Beger, R Somasundaram, W Li, B Birebent, D Herlyn |
Journal | Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress
(Langenbecks Arch Chir Suppl Kongressbd)
Vol. 115
Issue Suppl I
Pg. 53-8
( 1998)
ISSN: 0942-2854 [Print] Germany |
Vernacular Title | Erste erfolgreiche Immunisierung von Pankreas- und kolorektalen Karzinompatienten mit CO17-1A-Vakzin. |
PMID | 14518212
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Clinical Trial, Phase II, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Neoplasm
- Antigens, Neoplasm
- Cancer Vaccines
- Cell Adhesion Molecules
- Epithelial Cell Adhesion Molecule
- Vaccines, DNA
- carcinoma-associated antigen 17-1A
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Topics |
- Aged
- Antibodies, Neoplasm
(blood)
- Antigens, Neoplasm
(immunology)
- Cancer Vaccines
(immunology, therapeutic use)
- Cell Adhesion Molecules
(immunology)
- Colorectal Neoplasms
(immunology, surgery)
- Combined Modality Therapy
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Epithelial Cell Adhesion Molecule
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Pancreatic Neoplasms
(immunology, surgery)
- Vaccines, DNA
(immunology, therapeutic use)
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