Abstract |
In a double-blind study, 346 patients with active rheumatoid arthritis were randomly assigned to receive Arthrotec, a combination of 50 mg of diclofenac and 200 *g of misoprostol, or 50 mg of diclofenac; the drugs were given two or three times daily for 12 weeks. At weeks 4, 8, and 12 of treatment, no clinically significant differences between the two treatment groups were noted on measures of joint tenderness, pain, and swelling or on physicians' and patients' assessments of disease severity.
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Authors | J R Hannequin |
Journal | Scandinavian journal of rheumatology. Supplement
(Scand J Rheumatol Suppl)
Vol. 96
Pg. 7-14
( 1992)
ISSN: 0301-3847 [Print] Norway |
PMID | 1439627
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Arthrotec
- Drug Combinations
- Misoprostol
- Diclofenac
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Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Arthritis, Rheumatoid
(drug therapy)
- Diclofenac
(administration & dosage, standards, therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Combinations
- Female
- Humans
- Male
- Middle Aged
- Misoprostol
(administration & dosage, standards, supply & distribution, therapeutic use)
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