Tumorigenic effect of 4-methylphenylhydrazine hydrochloride in Swiss mice.

Abstract

4-Methylphenylhydrazine hydrochloride was administered as 10 weekly subcutaneous injections of 140 microgram/g body weight and as 7 weekly intragastric instillations of 250 microgram/g body weight in physiological saline to randomly bred Swiss mice. Treatments given subcutaneously resulted in induction of lung tumors in incidences of 36% in females and 44% in males, while intragastric treatment caused a 40% incidence in females. In addition, it gave rise to blood vessel tumors by intragastric route in incidences of 32% in females and 18% in males. In the two physiological saline-treated control groups, the lung tumor incidence (combined) was 20% in females and 21% in males, while the blood vessel tumor incidence (combined) was 7% in females and 6% in males. Histopathologically, the lesions were classified as adenomas and adenocarcinomas of the lungs, and angiomas and angiosarcomas of blood vessels. 4-Methylphenylhydrazine was postulated to be a metabolite of 4-hydroxymethylphenylhydrazine, an ingredient of the commonly eaten mushroom Agaricus bisporus. The implications are discussed with respect to the tumorigenesis data.

• Authors: B Toth, A Tompa, K Patil
• Journal: Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology (Z Krebsforsch Klin Onkol Cancer Res Clin Oncol) Vol. 89 Issue 3 Pg. 245-52 (Aug 15 1977) ISSN: 0084-5353 [Print] Germany
• PMID: 143810 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Methylhydrazines

Topics

• Animals
• Basidiomycota (analysis)
• Carcinogens
• Female
• Lung Neoplasms (chemically induced)
• Male
• Methylhydrazines (adverse effects, analysis)
• Mice
• Neoplasms, Vascular Tissue (chemically induced)