Metronidazole.

Abstract

Metronidazole has proven to be a useful and inexpensive antibiotic for the treatment of T. vaginalis and bacterial vaginosis. Few alternatives exist for these two specific indications, and metronidazole will continue to play a primary role in therapy. Oral metronidazole continues to be a very inexpensive alternative to oral vancomycin for the treatment of C. difficile-induced pseudomembranous colitis. For the treatment of moderate to severe mixed aerobic/anaerobic pelvic infections, metronidazole should be considered secondarily in patients who have failed other multiple- or single-drug regimens or in patients who are infected. with anaerobic organisms resistant to other commonly used agents including clindamycin, cefoxitin, cefotetan, or ampicillin/sulbactam. Metronidazole is not a first line drug of choice for antibiotic prophylaxis in obstetric and gynecologic patients.

• Authors: W D Hager, R P Rapp
• Journal: Obstetrics and gynecology clinics of North America (Obstet Gynecol Clin North Am) Vol. 19 Issue 3 Pg. 497-510 (Sep 1992) ISSN: 0889-8545 [Print] United States
• PMID: 1436927 (Publication Type: Journal Article, Review)

Chemical References

• Metronidazole

Topics

• Bacterial Infections (drug therapy)
• Costs and Cost Analysis
• Drug Interactions
• Drug Resistance, Microbial
• Enterocolitis, Pseudomembranous (drug therapy)
• Female
• Genital Diseases, Female (drug therapy)
• Humans
• Metronidazole (adverse effects, chemistry, therapeutic use)
• Pregnancy
• Pregnancy Complications, Parasitic (drug therapy)
• Trichomonas Vaginitis (drug therapy)
• Vaginosis, Bacterial (drug therapy)