[Has N-isopropyl-N'-phenylparaphenylenediamine a place among standard allergens? Importance of this allergen in rubber intolerance].

Abstract

Allergic contact dermatitis to N-isopropyl-N'-phenylparaphenylenediamine (IPPD) from rubber is far from being exceptional. Out of a total of 56 cases of allergic contact dermatitis to IPPD, 42 were considered as caused by occupational contacts: 17 cases were found in tyre manufacturers, 9 in car-mechanics, 9 in drivers, and 7 in various industrial branches. Out of the 56 cases, 23 also reacted allergically to mercaptobenzothiazole or to tetramethylthiuramdisulphide, or to both of these substances. In a chromatographic analysis of samples of 9 different tyre brands, IPPD was found in 8 cases.

• Authors: J Foussereau, C Cavelier
• Journal: Dermatologica (Dermatologica) Vol. 155 Issue 3 Pg. 164-7 ( 1977) ISSN: 0011-9075 [Print] Switzerland
• Vernacular Title: La N-isopropyl'N'-phénylparaphénylènediamine a-t-elle sa place dans la batterie standard d'allergènes? Importance de cet allergène dans l'intolérance au caoutchouc.
• PMID: 142669 (Publication Type: Journal Article)

Chemical References

• Allergens
• Phenylenediamines
• Thiram
• Rubber
• N-isopropyl-N-phenyl-4-phenylenediamine
• Mercaptopurine

Topics

• Allergens
• Chemical Phenomena
• Chemistry
• Dermatitis, Contact
• Dermatitis, Occupational (chemically induced)
• Humans
• Mercaptopurine (adverse effects)
• Phenylenediamines (adverse effects)
• Rubber (adverse effects)
• Thiram (adverse effects)