Dose-response of rt-PA and its combination with aspirin in a rat embolic stroke model.

Abstract

The efficacy and safety of thrombolysis with different dose regimens of recombinant tissue plasminogen activator (rt-PA) and its combination with aspirin was tested in an embolic stroke model. In rats the carotid territory was embolized with a single clot formed in a polyethylene tube and washed with saline. Fifteen minutes after embolization 10 animals were treated with rt-PA 10 mg kg-1; 11 with 15 mg kg-1; 12 with 20 mg kg-1 and 9 with 10 mg kg-1 + 20 mg kg-1 aspirin and 34 animals with saline. Rt-PA 10 mg kg-1 reduced median infarct volume (in percent of the ipsilateral hemisphere volume) from 19.5 to 4.8; rt-PA 15 mg kg-1 to 2.0; rt-PA 20 mg kg-1 to 0.0, while rt-PA 10 mg kg-1 + aspirin resulted in a median infarct volume of 9.5%. Thrombolytic therapy significantly and dose dependently (p = 0.001) reduced the infarct volume, improved the presacrifice clinical score and increased (p = 0.02) angiographically verified reperfusion. There was no additional benefit of coadministration of aspirin.

• Authors: K Overgaard, T Sereghy, H Pedersen, G Boysen
• Journal: Neuroreport (Neuroreport) Vol. 3 Issue 10 Pg. 925-8 (Oct 1992) ISSN: 0959-4965 [Print] England
• PMID: 1421100 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrinolytic Agents
• Recombinant Proteins
• Tissue Plasminogen Activator
• Aspirin

Topics

• Animals
• Aspirin (therapeutic use)
• Blood Gas Analysis
• Blood Pressure (drug effects)
• Carotid Artery Thrombosis (drug therapy)
• Cerebral Angiography
• Cerebral Infarction (drug therapy, pathology, physiopathology)
• Cerebrovascular Circulation (drug effects)
• Cerebrovascular Disorders (drug therapy)
• Dose-Response Relationship, Drug
• Fibrinolytic Agents (therapeutic use)
• Male
• Rats
• Rats, Sprague-Dawley
• Recombinant Proteins (therapeutic use)
• Tissue Plasminogen Activator (therapeutic use)