Selective localization of radioiodinated alkylphosphocholine derivatives in tumors.

Abstract

We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimethyl-N-(m[125I]iodobenzyl)-ammonium] ethyl phosphate (NM-326) demonstrated the ability of such compounds to localize in and thereby visualize the Walker 256 tumor in rats. However, the tumor avidity of NM-324 was far superior to NM-326. In addition, NM-324 showed excellent tumor localization in athymic mice bearing subcutaneous human tumors.

• Authors: K P Plotzke, T Haradahira, L Stancato, N M Olken, S Skinner, M D Gross, R L Wahl, R E Counsell
• Journal: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology (Int J Rad Appl Instrum B) Vol. 19 Issue 7 Pg. 765-73 (Oct 1992) ISSN: 0883-2897 [Print] England
• PMID: 1399698 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Iodine Radioisotopes
• Phospholipid Ethers
• NM 326
• NM 324

Topics

• Animals
• Carcinoma 256, Walker (diagnostic imaging)
• Female
• Iodine Radioisotopes
• Liver (metabolism)
• Phospholipid Ethers (chemical synthesis, pharmacokinetics)
• Radionuclide Imaging
• Rats
• Rats, Wistar
• Tissue Distribution