[Alterations of Ulex europaeus agglutinin-1 receptor in human colorectal benign and malignant tumors].

Abstract

The distributions and alterations of UEA-1 receptor in 116 human colorectal mucosa, included 20 normal mucosa, 16 inflammatory and 14 hyperplastic polyps, 34 adenomas, and 32 carcinomas, were studied with ABC technique. The results follow as: 1. There were positive staining of UEA-1 in proximal colon and negative in distal colon and rectum; 2. The frequency and intensity of UEA-1 receptor stained were increasing with the sequence of normal mucosa (7.7%), inflammatory polyps (25%), hyperplastic polyps (57.1%), adenomas (76.4%), and carcinomas (100%) in distal colon and rectum; 3. The staining pattern of UEA-1 in severe atypia adenomas was very similar to that in carcinomas and both of them were significantly difference from that in the other groups (P less than 0.05 or less than 0.01). The results suggested that UEA-1 receptor in distal colon and rectum may be considered as a probe studying course of malignant transformation and benefit to the diagnosis of carcinoma.

• Authors: B Han, T Deng, J P Yu
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 31 Issue 1 Pg. 26-8, 60 (Jan 1992) ISSN: 0578-1426 [Print] China
• PMID: 1395909 (Publication Type: English Abstract, Journal Article)

Chemical References

• Receptors, Cell Surface
• Receptors, Mitogen
• Ulex europaeus lectin receptor

Topics

• Adenoma (metabolism)
• Carcinoma (metabolism)
• Colonic Neoplasms (metabolism)
• Humans
• Immunoenzyme Techniques
• Intestinal Mucosa (metabolism)
• Intestinal Polyps (metabolism)
• Receptors, Cell Surface
• Receptors, Mitogen (metabolism)
• Rectal Neoplasms (metabolism)