Abstract |
The effects of FK664, a novel positive inotropic agent, and enoximone on pentobarbital-induced heart failure were compared in dog heart-lung preparations. Both FK664 and enoximone improved the cardiac function curve in a dose-dependent manner and restored it to the control level at drug concentrations of 1 microgram/ml and 10 micrograms/ml, respectively. Therefore, the cardiotonic potency of FK664 appears to be 10 times that of enoximone. These agents were almost equal in force-rate separation of cardiac effect. Neither of the agents produced arrhythmia at any dose tested. These results suggest that FK664 may be a potent cardiotonic agent for the treatment of heart failure.
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Authors | Y Sudo, M Takai, K Esumi |
Journal | Life sciences
(Life Sci)
Vol. 51
Issue 6
Pg. PL41-6
( 1992)
ISSN: 0024-3205 [Print] Netherlands |
PMID | 1386131
(Publication Type: Journal Article)
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Chemical References |
- Cardiotonic Agents
- Imidazoles
- Pyrimidinones
- FK 664
- Enoximone
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Topics |
- Animals
- Cardiotonic Agents
(therapeutic use)
- Disease Models, Animal
- Dogs
- Dose-Response Relationship, Drug
- Enoximone
- Extracorporeal Circulation
- Heart
(drug effects, physiology)
- Heart Failure
(chemically induced, physiopathology, prevention & control)
- Imidazoles
(therapeutic use)
- Lung
(drug effects, physiology)
- Pyrimidinones
(therapeutic use)
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