Tin-mesoporphyrin in the treatment of severe hyperbilirubinemia in a very-low-birth-weight infant.

Abstract

Tin-mesoporphyrin (SnMP) is a competitive inhibitor of microsomal heme oxygenase (the rate-limiting enzyme in the heme catabolic pathway). It was administered as a single intramuscular dose at 46 hours of life to a very-low-birth-weight infant with severe hemolytic hyperbilirubinemia who had been awaiting an exchange transfusion. This case documents the effective elimination of the need for an exchange transfusion in a very-low-birth-weight infant and is a confirmation of the experience of others for the use of SnMP in reducing bilirubin production.

• Authors: Pradeep Reddy, Shakuntala Najundaswamy, Rajeev Mehta, Anna Petrova, Thomas Hegyi
• Journal: Journal of perinatology : official journal of the California Perinatal Association (J Perinatol) Vol. 23 Issue 6 Pg. 507-8 (Sep 2003) ISSN: 0743-8346 [Print] United States
• PMID: 13679941 (Publication Type: Case Reports, Journal Article)

Chemical References

• Enzyme Inhibitors
• Metalloporphyrins
• Protoporphyrins
• tin protoporphyrin IX
• Heme Oxygenase (Decyclizing)

Topics

• Enzyme Inhibitors (administration & dosage, therapeutic use)
• Heme Oxygenase (Decyclizing) (antagonists & inhibitors)
• Humans
• Infant, Newborn
• Infant, Very Low Birth Weight
• Injections, Intramuscular
• Jaundice, Neonatal (drug therapy)
• Male
• Metalloporphyrins (administration & dosage, therapeutic use)
• Protoporphyrins (administration & dosage, therapeutic use)