Abstract | BACKGROUND: METHODS: A Markov model simulated progression from nephropathy to DSC, ESRD and death in patients with hypertension, type 2 diabetes and overt nephropathy. Treatment-specific probabilities were derived from IDNT. Country-specific ESRD-related data were retrieved from published sources. Delay in onset of ESRD, life expectancy and mean lifetime costs were calculated for patients with a baseline age of 59 years. Future costs were discounted at 3% per annum (p.a.), and clinical benefits were discounted at 0 and 3% p.a. Extensive sensitivity analyses were performed. RESULTS: Onset of ESRD was delayed with irbesartan by 1.41 and 1.35 years vs amlodipine and control, respectively. When a 10-year time horizon was considered, delay in ESRD onset led to anticipated improvements in life expectancy of 0.13 years vs amlodipine and 0.26 years vs control. Irbesartan was associated with cost savings of 14 949 and 9205/patient in Belgium, and 20 128 and 13 337 in France, vs amlodipine and control, respectively. The results were robust under a wide range of plausible assumptions. CONCLUSIONS:
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Authors | Andrew J Palmer, Lieven Annemans, Stephane Roze, Mark Lamotte, Roger A Rodby, Daniel J Cordonnier |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 18
Issue 10
Pg. 2059-66
(Oct 2003)
ISSN: 0931-0509 [Print] England |
PMID | 13679481
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Biphenyl Compounds
- Tetrazoles
- Irbesartan
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Topics |
- Adult
- Age of Onset
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(economics, therapeutic use)
- Belgium
- Biphenyl Compounds
(economics, therapeutic use)
- Case-Control Studies
- Cost-Benefit Analysis
- Diabetes Mellitus, Type 2
(complications)
- Diabetic Nephropathies
(complications)
- Female
- France
- Humans
- Hypertension
(drug therapy, economics)
- Incidence
- Irbesartan
- Kidney Failure, Chronic
(prevention & control)
- Life Expectancy
- Male
- Markov Chains
- Middle Aged
- Multicenter Studies as Topic
- Probability
- Risk Assessment
- Tetrazoles
(economics, therapeutic use)
- Treatment Outcome
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