Improving placental blood flow in pre-eclampsia with prostaglandin A1.

Abstract

Prostaglandin A1 is a potent hypotensive, peripheral vasodilator, a weak oxytocic, antiplatelet aggregator. It improves the renal hemodynamics. Its effect on placental circulation was evaluated (expressed as systolic/diastolic ratio and umbilical artery resistance index) in 20 women with severe pre-eclampsia and 10 normotensive pregnant women, by using the Doppler technique. Moreover, another 10 women with severe pre-eclampsia received dextrose 5% as a placebo for comparative purposes. Significant improvements in both parameters studied were observed in the women with severe pre-eclampsia. The beneficial changes differed significantly from the recorded values when using dextrose in pre-eclampsia or prostaglandin A1 in normotensive subjects. Such promising data add another important perspective to prostaglandin A1 in severe pre-eclampsia and may open up new avenues for its use in other situations with compromised placental flow.

• Authors: M Toppozada, I Medhat, H Sallam, A A Ismail, E S el-Badawy, S Abd Rabbo
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 71 Issue 1 Pg. 22-7 (Jan 1992) ISSN: 0001-6349 [Print] United States
• PMID: 1315092 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Prostaglandins A

Topics

• Adult
• Blood Pressure (drug effects)
• Diastole (drug effects)
• Female
• Fetus (blood supply)
• Humans
• Placenta (blood supply)
• Pre-Eclampsia (drug therapy, physiopathology)
• Pregnancy
• Prostaglandins A (therapeutic use)
• Regional Blood Flow
• Systole (drug effects)
• Ultrasonography, Prenatal
• Umbilical Arteries (physiology)
• Vascular Resistance (drug effects)