Leukemia in growth-hormone-treated patients: an update, 1992.

Abstract

Since 1988 the number of growth hormone (GH)-treated patients has markedly increased worldwide. To date, leukemia has been observed in 31 patients during or following GH therapy and related malignancies in 2 further patients. Leukemia occurred in 10 patients in Japan, 10 in the USA, and 10 in Europe, and in 1 patient in Canada. In 29 patients GH therapy had been started in 1975 or later. The onset of leukemia was 1984 or later in 28 patients with a mean time between the start of GH therapy and leukemia onset of 5.0 (0.2-18.8) years. Patients had received both pituitary and recombinant GH in moderate doses. In 15 patients definite additional leukemia risk was evident: Fanconi anemia in 2, myelodysplastic syndrome in 1, Bloom's syndrome in 1, radiation for brain tumor (+chemotherapy) in 9, chemotherapy in 2. The leukemic patients without a strong additional risk do not represent a definitely higher leukemia incidence worldwide, except for Japan where the occurrence is higher than expected.

• Authors: N Stahnke
• Journal: Hormone research (Horm Res) Vol. 38 Suppl 1 Pg. 56-62 ( 1992) ISSN: 0301-0163 [Print] Switzerland
• PMID: 1295814 (Publication Type: Journal Article, Review)

Chemical References

• Growth Hormone

Topics

• Adolescent
• Child
• Child, Preschool
• Growth Hormone (adverse effects, deficiency, therapeutic use)
• Hematopoiesis (drug effects)
• Humans
• In Vitro Techniques
• Leukemia (epidemiology, etiology)
• Risk Factors