Abstract |
The 80% aqueous acetone extract of the rhizomes of Alpinia galanga was found to inhibit release of beta-hexosaminidase, as a marker of antigen- IgE-mediated degranulation in RBL-2H3 cells. Nine known phenylpropanoids and p-hydroxybenzaldehyde were isolated from the extract. Among them, 1'S-1'-acetoxychavicol acetate and 1'S-1'-acetoxyeugenol acetate exhibited potent inhibitory activity with IC(50) values of 15 and 19 microM. From the effects of various related compounds, both the 1'- and 4-acetoxyl groups of 1'S-1'-acetoxychavicol acetate and 1'S-1'-acetoxyeugenol acetate were essential for their strong activity, and the 2'-3' double bond enhanced the activity. In addition, 1'S-1'-acetoxychavicol acetate and 1'S-1'-acetoxyeugenol acetate inhibited ear passive cutaneous anaphylaxis reactions in mice and the antigen- IgE-mediated TNF-alpha and IL-4 production, both of which participate in the late phase of type I allergic reactions, in RBL-2H3 cells.
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Authors | Hisashi Matsuda, Toshio Morikawa, Hiromi Managi, Masayuki Yoshikawa |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 13
Issue 19
Pg. 3197-202
(Oct 06 2003)
ISSN: 0960-894X [Print] England |
PMID | 12951092
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Allergic Agents
- Phenylpropionates
- Plant Extracts
- Tumor Necrosis Factor-alpha
- Interleukin-4
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Topics |
- Alpinia
- Animals
- Anti-Allergic Agents
(chemistry, pharmacology)
- Cell Degranulation
(drug effects, immunology)
- Cell Line, Tumor
- Interleukin-4
(antagonists & inhibitors, biosynthesis, metabolism)
- Male
- Mast Cells
(drug effects, metabolism)
- Mice
- Passive Cutaneous Anaphylaxis
- Phenylpropionates
(chemistry, pharmacology)
- Plant Extracts
(chemistry, pharmacology)
- Rats
- Rhizome
- Structure-Activity Relationship
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors, biosynthesis, metabolism)
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