Abstract | BACKGROUND: METHODS: RESULTS: NR and resuscitation with DL-LR increased the expression of apoptotic markers, whereas resuscitation with KR and PR significantly decreased the expression of apoptotic markers in rat lungs. Resuscitation with KR was followed by a profound increase in plasma BHB levels; however, the expression levels of ketolytic enzymes were essentially unaffected. KR infusion did not induce significant improvements in tissue ATP levels. CONCLUSIONS:
Resuscitation with KR and PR protects against pulmonary apoptosis without improving tissue ATP content. Therefore, metabolic modulation is unlikely to be the major mechanism by which BHB exerts its protective effects during reperfusion.
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Authors | Elena Koustova, Peter Rhee, Timothy Hancock, Huazhen Chen, Ryan Inocencio, Amin Jaskille, William Hanes, C Robert Valeri, Hasan B Alam |
Journal | Surgery
(Surgery)
Vol. 134
Issue 2
Pg. 267-74
(Aug 2003)
ISSN: 0039-6060 [Print] United States |
PMID | 12947328
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Isotonic Solutions
- Ringer's Lactate
- Pyruvic Acid
- Adenosine Triphosphate
- 3-Hydroxybutyric Acid
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Topics |
- 3-Hydroxybutyric Acid
(administration & dosage, blood)
- Adenosine Triphosphate
(metabolism)
- Animals
- Apoptosis
(drug effects)
- Energy Metabolism
(drug effects)
- Isotonic Solutions
(chemistry, pharmacology)
- Lung
(metabolism, physiopathology)
- Male
- Pyruvic Acid
- Rats
- Rats, Sprague-Dawley
- Resuscitation
- Ringer's Lactate
- Severity of Illness Index
- Shock, Hemorrhagic
(blood, physiopathology, therapy)
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