Abstract | BACKGROUND: METHODS: The authors retrospectively reviewed 18 patients with thymic carcinoma who were treated between 1996 and 2002. Twelve of these patients had unresectable advanced diseases and received weekly chemotherapy according to the CODE regimen. The CODE regimen consisted of cisplatin (25 mg/m(2), intravenously [i.v.]; weekly administration), vincristine (1 mg/m(2), i.v.; administered during Weeks 1, 2, 4, 6, and 8), doxorubicin (40 mg/m(2), i.v.; administered during Weeks 1, 3, 5, 7, and 9), and etoposide (80 mg/m(2), i.v.; administered for 3 days during Weeks 1, 3, 5, 7, and 9). RESULTS: The responses of all 12 patients to the CODE regimen were assessed. A partial response was achieved in 5 patients, and the overall response rate was 42%. Only one patient experienced disease progression. The median progression-free survival period was 5.6 months (range, 2-39 months). The overall survival period ranged from 6 to 79 months, with a median survival period of 46 months. Based on the Kaplan-Meier method, the estimated 1-year and 2-year survival rates were 80% and 58%, respectively. The most common side effects were hematologic toxicities, and only mild nonhematologic toxicities were experienced. CONCLUSIONS:
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Authors | Kiyotaka Yoh, Koichi Goto, Gen-ichiro Ishii, Seiji Niho, Hironobu Ohmatsu, Kaoru Kubota, Ryutaro Kakinuma, Kanji Nagai, Moritaka Suga, Yutaka Nishiwaki |
Journal | Cancer
(Cancer)
Vol. 98
Issue 5
Pg. 926-31
(Sep 01 2003)
ISSN: 0008-543X [Print] United States |
PMID | 12942558
(Publication Type: Journal Article)
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Copyright | Copyright 2003 American Cancer Society. |
Chemical References |
- Vincristine
- Etoposide
- Doxorubicin
- Cisplatin
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects, therapeutic use)
- Carcinoma
(drug therapy, pathology)
- Cisplatin
(administration & dosage)
- Disease Progression
- Doxorubicin
(administration & dosage)
- Drug Administration Schedule
- Etoposide
(administration & dosage)
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Retrospective Studies
- Survival Analysis
- Thymus Neoplasms
(drug therapy, pathology)
- Treatment Outcome
- Vincristine
(administration & dosage)
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