Abstract | BACKGROUND: METHODS: Clinical measurements recorded included probing depth, attachment level, gingival erythema, bleeding upon probing, suppuration, and plaque. Disease progression was defined as a >2 mm loss of attachment 2 months post-baseline. Serum antibody was measured by enzyme-linked immunosorbent assay. CRP was measured using a high-sensitivity CRP ( hsCRP) assay. A commercial laboratory measured serum glucose (non-fasting), albumin, cholesterol, high-density lipoprotein (HDL), triglycerides, low-density lipoprotein ( LDL), and iron. RESULTS: Increased serum IgG antibody to Porphyromonas gingivalis, but not to 5 other species, was associated with periodontal disease status, increased severity, and progression as were age, male gender, and smoking. Cholesterol and LDL were increased in disease, and HDL and iron were increased in health. hsCRP, glucose, and cholesterol increased with disease progression. By regression analysis, IgG antibody to P. gingivalis correlated with age, probing depth, and hsCRP, and negatively correlated with albumin and iron. By logistic regression, subjects who experienced multiple sites of disease progression and elevated antibody to P. gingivalis increased the odds ratio of hsCRP>2.08 mg/l by 14.1 and 5.6, respectively. CONCLUSION:
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Authors | Ronald G Craig, Julie K Yip, Man Ki So, Robert J Boylan, Sigmund S Socransky, Anne D Haffajee |
Journal | Journal of periodontology
(J Periodontol)
Vol. 74
Issue 7
Pg. 1007-16
(Jul 2003)
ISSN: 0022-3492 [Print] United States |
PMID | 12931763
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Bacterial
- Blood Glucose
- Immunoglobulin G
- C-Reactive Protein
- Cholesterol
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Topics |
- Acute-Phase Reaction
(blood, complications)
- Adult
- Age Factors
- Aged
- Antibodies, Bacterial
(blood)
- Blood Glucose
(analysis)
- C-Reactive Protein
(analysis)
- Cholesterol
(blood)
- Female
- Follow-Up Studies
- Gingival Hemorrhage
(complications)
- Gingivitis
(complications)
- Humans
- Immunoglobulin G
(blood)
- Male
- Middle Aged
- Minority Groups
- Periodontal Attachment Loss
(complications)
- Periodontal Diseases
(blood, complications)
- Periodontal Pocket
(complications)
- Sex Factors
- Smoking
- Urban Health
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