[Successful treatment with cyclosporine in a case of progressive interstitial pneumonia associated with systemic sclerosis].

Abstract

A 55-year-old man was admitted to our hospital with dyspnea on effort and sclerodactyly. The chest radiograph showed reticulonodular shadows in both lower lung fields. A diagnosis of systemic sclerosis was made based on the characteristic skin lesions, interstitial pneumonia and the positivity for anti-Scl-70 antibody. Surgical biopsies were performed, which showed various features characteristic of organizing pneumonia and non-specific interstitial pneumonia. Prednisolone and cyclophosphamide were given to the patient, but clinical symptoms and chest radiographic findings worsened. After cyclophosphamide was replaced with cyclosporine, his symptoms, chest radiographic findings and pulmonary function improved and stabilized. It is suggested that cyclosporine is useful for the treatment of progressive interstitial pneumonia associated with systemic sclerosis.

• Authors: Tomoyuki Fujisawa, Takeshi Yagi, Jun Kobayashi, Hideki Suganuma, Takahisa Saito, Yoshimitsu Takashima, Yutarou Nakamura, Takafumi Suda, Kingo Chida, Hirotoshi Nakamura
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 41 Issue 7 Pg. 480-5 (Jul 2003) ISSN: 1343-3490 [Print] Japan
• PMID: 12931677 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Immunosuppressive Agents
• Cyclosporine
• Prednisolone

Topics

• Cryptogenic Organizing Pneumonia (complications, drug therapy)
• Cyclosporine (administration & dosage)
• Drug Therapy, Combination
• Humans
• Immunosuppressive Agents (administration & dosage)
• Lung Diseases, Interstitial (complications, drug therapy)
• Male
• Middle Aged
• Prednisolone (administration & dosage)
• Scleroderma, Systemic (complications)