Abstract |
Relying on the synergistic action on contractility of enoximone and dobutamine when concomitantly infused, 25 patients with their first acute Q-wave anterior myocardial infarctions underwent conventional low-dose dobutamine echocardiography (LDE) and enoximone very-LDE to assess myocardial viability in severely dysfunctioning areas. Images were recorded at peak of pharmacodynamic effect of drugs and 4 months after revascularization. At peak-dose stage of LDE and enoximone very-LDE the regional infarct zone wall-motion score significantly decreased from the basal value of 25.6 +/- 2.9 to 16 +/- 6.0 (P <.001) and to 14.5 +/- 5.2 (P <.001), respectively. A high correlation was found by comparing the wall-motion score of each patient calculated at peak effect of combined drug administration with follow-up values (r(s) = 0.9). Enoximone very-LDE has proven to be a new test useful to evaluate viability in asynergic segments especially when the results of conventional tests are questionable.
|
Authors | Enrico Mangieri, Gaetano Tanzilli, Francesco Barillà, Gaetano Pannitteri, Maria Cristina Acconcia, Roberto Mezzanotte, Roberto Donati, Cosimo Comito, Giuseppe Critelli |
Journal | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
(J Am Soc Echocardiogr)
Vol. 16
Issue 9
Pg. 942-8
(Sep 2003)
ISSN: 0894-7317 [Print] United States |
PMID | 12931106
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
|
Chemical References |
- Cardiotonic Agents
- Dobutamine
- Enoximone
|
Topics |
- Adult
- Blood Pressure
(drug effects, physiology)
- Cardiotonic Agents
(pharmacology)
- Dobutamine
(pharmacology)
- Dose-Response Relationship, Drug
- Dyskinesias
(diagnosis, physiopathology)
- Echocardiography, Stress
- Enoximone
(pharmacology)
- Female
- Follow-Up Studies
- Heart Rate
(drug effects, physiology)
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Myocardial Contraction
(drug effects, physiology)
- Myocardial Infarction
(diagnosis, physiopathology)
- Predictive Value of Tests
- Sensitivity and Specificity
- Severity of Illness Index
- Statistics as Topic
- Stimulation, Chemical
- Stroke Volume
(drug effects, physiology)
- Ventricular Dysfunction, Left
(diagnosis, physiopathology)
|