[Steroid-pulse therapy in Guillain-Barré syndrome associated with cytomegalovirus infection: a case report].

Abstract

We report a 27-year-old man with Guillain-Barré syndrome (GBS) preceded by cytomegalovirus infection. He was admitted to our hospital because of distal dominant weakness and sensory disturbance 5 days after fever. Double filtration plasmapheresis (DFPP) was performed and clinical symptoms temporary but dramatically improved. However facial nerve palsy, difficulty in swallowing food, weakness, dysautonomia and respiratory failure rapidly progressed within 5 days after the onset. Repeated DFPP failed to improve his symptoms. Two months after the onset, he did not improve at all. On T1-weighted MRI, nerve roots were still enhanced with gadolinium, and CSF examination revealed 1,324 mg/dl of protein. These findings suggested us the existence of continuous inflammation on nerve roots. We gave steroid-pulse therapy. He dramatically improved after this treatment. We repeated steroid-pulse therapy for seven times. He was discharged without any major complication 6 months after the onset. Steroid-pulse therapy should be considered in GBS patients associated with CMV infection when other conventional treatments are ineffective.

• Authors: Masayoshi Tada, Osamu Onodera, Izumi Kawachi, Kenju Hara, Masahisa Sato, Hiide Yoshino, Atsuko Asano, Yoshiaki Soma, Shoji Tsuji
• Journal: No to shinkei = Brain and nerve (No To Shinkei) Vol. 55 Issue 7 Pg. 615-21 (Jul 2003) ISSN: 0006-8969 [Print] Japan
• PMID: 12910997 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Immunoglobulin M
• G(M2) Ganglioside
• Prednisolone

Topics

• Adult
• Cytomegalovirus Infections (complications)
• Drug Administration Schedule
• G(M2) Ganglioside (immunology)
• Guillain-Barre Syndrome (complications, drug therapy, immunology)
• Humans
• Immunoglobulin M (immunology)
• Male
• Plasmapheresis
• Prednisolone (administration & dosage)
• Pulse Therapy, Drug