Abstract | BACKGROUND: METHODS: Totally 60 patients from 370 cases of biopsy-proved IgA nephropathy in our hospital between 1983 and 1999 met the selection criteria and were enrolled into this analysis. These patients received either corticosteroid alone or in combination with cyclophosphamide. The analysis of the progression of renal disease by serum creatinine and changes in the level of proteinuria were based on an on-treatment approach. Kidney survival curve was by Kaplan-Meier analysis and compared among different subgroups. RESULTS: Of the 60 patients, 20 cases (33.3%) (Group 1) reached a complete remission of proteinuria by prednisolone alone. The other cases received a combination therapy with corticosteroid and cyclophosphamide, which resulted in complete remission in 17 cases (28.3%) (Group 2), partial remission in 9 cases (15.0%) (Group 3) and complete resistance in 14 patients (23.3%) (Group 4). The renal survival rate was significantly worse in Group 4 (p < 0.05) as compared with other groups. CONCLUSIONS:
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Authors | Kuo-Jung Chen, Chi-Hung Cheng, Ming-Ju Wu, Cheng-Hsu Chen, Kuo-Hsiung Shu |
Journal | Journal of the Chinese Medical Association : JCMA
(J Chin Med Assoc)
Vol. 66
Issue 5
Pg. 263-70
(May 2003)
ISSN: 1726-4901 [Print] Netherlands |
PMID | 12908567
(Publication Type: Journal Article)
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Chemical References |
- Glucocorticoids
- Cyclophosphamide
- Prednisolone
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Topics |
- Adult
- Cyclophosphamide
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Female
- Glomerulonephritis, IGA
(complications, drug therapy, pathology)
- Glucocorticoids
(administration & dosage, therapeutic use)
- Humans
- Male
- Prednisolone
(therapeutic use)
- Proteinuria
(complications)
- Retrospective Studies
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