Liver transplantation in patients with fulminant hepatitis B: experience in Canton, China.

Abstract

OBJECTIVE:

To investigate the effect of orthotopic liver transplantation on fulminant hepatitis B and the preventive efficiency of lamivudine on recurrence of hepatitis B in China.

PATIENTS AND METHODS:

Ten patients with fulminant hepatitis B received orthotopic liver transplantation under veno-venous bypass. All patients had preoperatively serious jaundice, ascites and coagulopathy, and of whom 7 with encephalopathy, 2 with acute renal failure, and 1 with gastro-hemorrhage. RUSULT: Seven of the 10 patients have survived for 3 approximately 18 months, but 3 died of multi-organ failure or recurrence of fulminant hepatitis B. Seven survivors took lamivudine and 6 of them have survived for 3 approximately 18 months without the signs of recurrence of hepatitis B.

CONCLUSION:

Orthotopic liver transplantation is an effective therapy for fulminant hepatitis B, and lamivudine may prevent recurrence of hepatitis B after transplantation.

• Authors: Xiaofeng Zhu, Guihua Chen, Xiaoshun He, Minqiang Lu, Guodong Wang, Changjie Cai, Yang Yang, Jiefu Huang
• Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih (Chin Med Sci J) Vol. 17 Issue 1 Pg. 44-6 (Mar 2002) ISSN: 1001-9294 [Print] China
• PMID: 12894885 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lamivudine

Topics

• Adult
• Hepatic Encephalopathy (drug therapy, etiology, surgery)
• Hepatitis B (complications, drug therapy, surgery)
• Humans
• Lamivudine (therapeutic use)
• Liver Transplantation
• Male
• Middle Aged
• Recurrence
• Survival Rate